## Where does the “fire in the mouth” feeling come from? The alkaloid capsaicin, a substance named for the Capsicum family of peppers, causes the feeling of heat in the mouth When spicy food enters the mouth, capsaicin, and allyl isothiocyanate(from mustard, horseradish, and wasabi) bind to TRPV1 taste receptors. The receptors change the structure — and this is signaled via the trigeminal nerve to the brain, which perceives this as a signal of increased temperature in the mouth. The central nervous system then tries to cool the body: blood vessels dilate, blood circulation becomes more active, body temperature rises, intense sweating begins, and the concentration of endorphins in the blood increases. The nasal mucosa becomes inflamed, and the nose and eyes leak. The lungs send a hiccup signal to the diaphragm in an attempt to expel the fiery invader. This is all a natural reaction to spicy food. No matter how hot or spicy the food, internal tissues and organs will not be damaged. > For a 150 pound person, 4 ounces or more of capsaicin has the potential to be lethal. You should never seek to consume as much as you possibly can. ## How do you put out the "fire"? Drinking water ===is not very effective since capsaicin refers to fat-soluble compounds. Only molecules of alcohol and sugars will help, which is why some drink semi-sweet or sweet wines when eating spicy dishes. However, the best way to wash down spicy food is with milk as fats and milk proteins slow down the activation of capsaicin. ## What is the harm? __Eating spicy foods can bring on stomach problems.__ If you have eaten very spicy food, TRPV1 receptors are activated too intensively, and the brain begins to take action. This can bring on indigestion, nausea, and vomiting, especially if you have very active TRPV1 receptors. People with gastrointestinal diseases should avoid overly spicy foods, which can cause or aggravate acid reflux by irritating the gastric mucosa. __Heartburn can occur if a lot of spicy food has been consumed.__ This triggers the release of gastric juice into the esophagus. __Loss of taste can also occur.__ When this happens, ordinary food seems bland and tasteless. ## What are the benefits? __Improves digestion and helps you lose weight:__ moderately spicy food stimulates the secretion of gastric juices, speeds up digestion, and reduces appetite. Capsaicin and other compounds in chili peppers can increase fat oxidation. __Normalizes blood circulation:__ the heat released by the body when eating spicy foods dilates blood vessels and increases blood flow, thereby lowering blood pressure and preventing blood clots. Capsaicinoids also activate the breakdown processes of "bad" cholesterol. __Reduces the risk of [cancer](https://ul.orna.me/KOge/librarydisease?id=129):__ studies have shown that capsaicin can bind to proteins in tumor cells and kill them. Countries with higher consumption of spicy foods have a lower incidence of cancer. __Strengthens the immune system:__ capsaicin has antioxidant and anti-inflammatory properties. The substances in chili peppers kill pathogens in the gut and slow their reproduction. __Relieves pain:__ pure capsaicin is used in ointments to block pain, inflammation in joints, and muscle sprains. __Improves mood:__ according to American research, the activation of TRPV1 receptors releases endorphins into the bloodstream, which allow you to feel pleasure.