A study aimed at identifying IgG class antisperm antibodies for the diagnosis of immunological causes of infertility in men.

Antisperm antibodies are specific immunoglobulins directed to various parts of the sperm. They are produced by the immune system in response to contact with sperm antigens in violation of immunological self-tolerance. In healthy men, the presence and normal functioning of the hematotesticular barrier protects the components of the ejaculate (semen) from the effects of your own immune system. When this barrier is violated as a result of bacterial and viral infectious processes, testicular cancer, varicocele, cryptorchidism, trauma, and surgical interventions, an autoimmune reaction is triggered with the formation of specific autoantibodies.

IgG class antisperm antibodies come from the blood as a result of damage to the hematotesticular barrier and can persist in the ejaculate for a long time.

This test allows you to determine the percentage of normal spermatozoa coated with antibodies to the total number of normal spermatozoa with the same characteristics, but without the presence of antibodies. The MAP test should be performed at normal concentration and motility of spermatozoa assessed by a spermogram. Morphologically and functionally normal spermatozoa, but having antisperm antibodies on their surface, are not involved in the fertilization process and can cause infertility in men.